乳头溢液中CEA、CA153的表达与乳腺良恶性疾病关系的临床研究
Chinese Journal of Current Advances in General Surgery(2018)
Abstract
目的:探讨乳头溢液中CEA及CA153的表达对良恶性乳腺疾病的诊断价值.方法:477例乳头溢液标本(乳腺癌1 34例,良性乳腺疾病343例)均检测CEA及CA153水平,并计算阳性预测值和阴性预测值为95%的截断值.结果:乳头溢液中CEA及CA153水平在良恶性疾病组中有差别,乳腺癌组表达水平均明显高于良性乳腺疾病组(P值均<0.001).当阴性预测值为95%时,CEA的值为55.8 ng/mL,CA153的值为177.3 U/mL;阳性预测值为95%时,CEA的值为594.5 ng/mL,CA153的值为9775U/mL.结论:不同乳腺疾病其CEA及CA153表达水平有明显差异,乳头溢液中CEA和CA153检测有助于临床鉴别诊断乳腺良、恶性疾病,可作为乳头溢液疾病的临床检查.
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