血清miRNA在肝癌患者中的表达水平变化检测
Journal of Hepatobiliary Surgery(2018)
Abstract
目的 检测肝癌患者血清中miRNA的表达水平.方法 提取肝癌患者血清中的miRNA进行芯片杂交测序,并用qRT-PCR的方法比较确定患者miRNA与健康对照的表达水平变化,检测手术前手术后肝癌患者血清中相关miRNA的表达水平变化.结果 与健康对照组相比,肝癌患者血清中hsa-miR-206、hsa-miR-20a-3p、hsa-miR-411-5p、hsa-miR-122和has-miR-423水平明显升高,术后hsa-miR-206、hsa-miR-411-5p、hsa-miR-122和has-miR-423水平显著降低;hsa-miR-26a-5p、hsa-miR-455-5p、hsa-miR-30e-3p、hsa-let-7f-5p和hsa-miR-6852水平显著降低,术后hsa-miR-26a-5p和hsa-miR-455-5p水平显著回升.结论 血清miRNA可作为肝癌诊断的依据,并能反映疾病发展过程.
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