早期应激对雄性大鼠海马神经发生的影响
Chinese Journal of Neurosurgical Disease Research(2015)
Abstract
目的:观察早期应激对雄性大鼠海马神经发生的影响。方法在出生后2~14 d对大鼠实施母子分离,免疫荧光染色观察海马齿状回的未成熟神经元数目( doublecortin, DCX)和细胞的增殖( Ki67)的表达。结果经历母子分离的雄性大鼠海马的DCX+细胞数目极其显著多于对照组的(P<0.001),而细胞增殖却显著减少(P<0.05)。结论本研究证实大鼠在新生期经历母爱剥夺(每日3 h,出生后第2~14 d),会影响成年后海马的神经发生。
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Key words
Early life stress,Maternal separation,Neurogenesis,Hippocampus,Male rats
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