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siRNA抑制小胶质细胞上TLR4的表达

刘思兰,杨建平,王丽娜,刘磊,李彩芳,任春光,周静,李伟,江淼,马珍妮,邱桥成

CHINESE JOURNAL OF EXPERIMENTAL SURGERY（2010）

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Abstract
应用siRNA转染体外培养的原代大鼠大脑皮质和海马神经元,干扰外源导人基因或内源基因的表达已取得成功.我们设计了4条大鼠小胶质细胞Toll样受体4(TLR4)的siRNA,对比研究基因干扰对小胶质细胞上的TLR4基因表达和蚩白水平的影响.
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