FSH和LH联合上调卵巢上皮性癌细胞侵袭能力的机制研究

Chinese Journal of Obstetrics and Gynecology（2014）

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Abstract

卵巢上皮性癌(卵巢癌)的病死率居妇科恶性肿瘤之首,约90％的卵巢癌被认为起源于正常卵巢表面上皮(ovarian surface epithelium,OSE)或内衬OSE的包涵囊肿[1].但卵巢癌发生发展的确切机制尚不明确.卵巢癌病情隐匿,易出现侵袭和转移,70％的患者确诊时已处于晚期[2].目前认为,妇女绝经后或卵巢功能不全者存在高促性腺激素状态,FSH和LH持续刺激可导致细胞过度增殖,最终可引发卵巢癌[3].

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