重度子痫前期及子痫孕妇外周血中FNRBC与EPO和NP-A水平的相关性
CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY(2011)
Abstract
子痫前期及子痫是妊娠期的严重并发症,是导致孕产妇和围产儿病率和死亡率上升的主要原因之一.目前,子痫前期及子痫的发病机制尚未完全明确,有研究发现,子痫前期及子痫的发生,与胎儿细胞、滋养层细胞、合体滋养细胞穿透胎盘屏障进入母体增加有关[1-2].孕妇外周血中胎儿有核红细胞(fetal nucleated red blood cells,FNRBC)的检测已经广泛用于无创性产前诊断研究,子痫前期孕妇血循环中FNRBC数量增加,提示子痫前期的发生与FNRBC穿过胎盘屏障相关[3-4].
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