神经激肽1受体阻断剂——缓解化疗所致恶心呕吐的新选择
Oncology Progress(2013)
Abstract
恶心与呕吐是化疗过程中最常出现的毒副反应,且常使肿瘤患者对化疗不能耐受而导致治疗中断.目前,我国临床上使用的化疗止吐药物主要为5-羟色胺(5-hydroxytryptamine,5-HT3)受体阻断剂与皮质激素.然而,此类药物对于化疗所致的急性及延迟性恶心呕吐的控制仍存在局限性.多项研究证实,神经激肽1(neurokinin-1,NK-1)受体阻断剂在防治化疗所致恶心呕吐(chemotherapy-induced nausea and vomiting,CINV)方面具有临床价值,该类药物的使用提高了化疗患者的依从性.本文就NK-1受体阻断剂在肿瘤化疗止吐中的临床应用予以综述.
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