血浆miR-92a与骨肉瘤预后相关性研究
wf(2016)
Abstract
背景与目的:骨肉瘤是儿童和年轻成人最常见的原发性恶性骨肿瘤,目前尚无高特异度、高灵敏度的预后预测指标。该研究旨在探讨血浆miR-92a表达水平与骨肉瘤临床病理及预后的关系。方法:收集30例健康体检者和45例骨肉瘤患者术前及术后血浆,通过实时荧光定量聚合酶链反应(real-time fluorescent quantitative polymerase chain reaction,RTFQ-PCR)检测血浆miR-92a水平。以术前miR-92a≥5为界限,将骨肉瘤患者分为高表达组和低表达组。结果:骨肉瘤患者血浆miR-92a水平显著高于正常体检人群,患者术前miR-92a水平远高于术后。患者术前miR-92a表达水平与患者的性别、年龄、肿瘤部位、肿瘤大小和组织学类型等无关,而与Enneking分期、肿瘤坏死率和肺转移相关。Kaplan-Meier分析高表达miR-92a的骨肉瘤预后差(P=0.035)。结论:骨肉瘤患者血浆miR-92a表达水平与生存率相关,可能是骨肉瘤一项有价值的预后指标。
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Key words
Osteosarcoma,miR-92a,Real-time lfuorescent quantitative polymerase chain reaction
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