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PI3K/Akt/mTOR信号通路在上皮源性恶性肿瘤中的研究进展

Juan Zhang,Dan Xu,Li He,Hongduo Chen

Journal of Modern Oncology（2017）

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Abstract
磷脂酰肌醇3-激酶/蛋白激酶B/哺乳类动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路不仅与细胞的增殖、存活及迁移密切相关,其与肿瘤的发生和发展也具有相关性.近年来,以该通路作为抗肿瘤治疗的靶点已成为研究的热点.本文就PI3K/Akt/mTOR信号通路在上皮来源恶性肿瘤活化、发生、发展中的作用,特别是皮肤鳞癌中的最新研究进展作一综述,并为皮肤肿瘤治疗及新药开发做一展望.
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Key words
PI3K/Akt/mTOR,signaling pathways,epithelial malignant tumor,squamous cell carcinomas,actinic keratosis
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