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慢性粒细胞白血病相关抗原HLA-A2.1限制性CTL表位的生物信息学分析

Wei Fu,Song Wang,Chunmei Ban,Dong Xie,Yongjing Luo,Yingmin Liang

Journal of Modern Oncology（2016）

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Abstract
目的:预测慢性粒细胞白血病BCR/ABL融合基因HLA-A2.1限制性细胞毒性T细胞表位.方法:运用BIMAS、SYFPEITHI、Predep、Immune Epitope Database和Analysis Resource(IEDB)软件预测BCR/ABL融合基因可能的HLA-A2.1限制性CTL表位.结果:结合BIMAS、SYFPEITHI、Predep和IEDB预测BCR/ABL融合基因的HLA-A2.1限制性CTL表位,共6条.结论:综合运用多个预测软件可提高预测效率获得目的表位肽,为下一步基础实验打下基础.
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Key words
chronic myeloid leukemia,BCR/ABL,CTL epitope
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