替吉奥胶囊联合吉西他滨治疗晚期胰腺癌的疗效分析
JOURNAL OF MODERN ONCOLOGY(2014)
Abstract
目的:观察替吉奥(S-1)胶囊联合吉西他滨治疗晚期胰腺癌的临床疗效和安全性.方法:采用非盲法随机对照试验.试验组18例,替吉奥(S-1)胶囊联合吉西他滨,替吉奥(S-1)胶囊每天80mg/m2,分2次,餐后口服,d1-14,吉西他滨1000mg/m2,静脉滴注,30min,d1、8;对照组18例,吉西他滨1000mg/m2,静脉滴注,30min,d1、8、15;两组28天1个周期.结果:实验组有效率(CR+PR)为44.4%,MST为7.6个月.主要毒副反应为血液学毒性和消化道反应.结论:替吉奥(S-1)胶囊联合吉西他滨是治疗晚期胰腺癌的一种安全有效的化疗方案.
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