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人源性肿瘤组织异种移植模型的建立及应用

Zhenyu YIN,Qian LIU,Xiaomei LI,Wenbo QI,Le LIU,Yuping BAI,Yanling MA,Hao CHEN

Cancer Research on Prevention and Treatment（2020）

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Abstract
人源性肿瘤组织异种移植(PDTX)模型是指将患者新鲜的肿瘤组织移植到免疫缺陷小鼠,依靠小鼠提供的微环境生长的一种异种肿瘤移植模型.此模型高度保留了原代肿瘤的生物学特征,维持了肿瘤细胞生长的微环境,可代替患者进行临床前试验研究,为临床前药效的评估、个体化治疗方案的筛选提供了有效的研发基础.本文就PDTX模型在肿瘤研究中的建立、临床应用及其局限性进行综述.
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patient-derived
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