DDAH2C-449G基因多态性与动脉粥样硬化血栓形成性脑梗死的相关性
Stroke and Nervous Diseases（2016）
Abstract
目的 探讨DDAH2C-449G基因多态性与动脉粥样硬化血栓形成性脑梗死(atherothrombotic infarct ofbrain)的关系.方法 共纳入345例脑梗死患者和201例对照组人群,以DDAH2C-449G基因为遗传标志,采用聚合酶链式反应(PCR)和限制性片段长度多态性技术(RFLP)检测DDAH2C-449G基因多态性.结果 动脉粥样硬化血栓形成性脑梗死GG基因型、G等位基因频率较对照组高(P＜0.05).结论 DDAH2C-449G基因多态性可能与动脉粥样硬化血栓形成性脑梗死发病有关,G等位基因可能是动脉粥样硬化血栓形成性脑梗死的易感基因.
MoreKey words
Atherothrombotic cerebral infarction,Genetics,Gene,DDAH2C-449G,Polymerase chain reaction
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