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NADPH氧化酶p22phox亚基基因多态性与急性动脉硬化性脑梗死的关联性研究

Xiao-xi LI,Wen-jing LIU,Wen-juan JIANG,Qu LI,Rui-xia ZHU,Xu LIU,Zhi-yi HE

Chinese Journal of Clinical Neurosciences（2017）

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Abstract
目的 探讨CYBA基因的多态性位点与急性动脉硬化性脑梗死的相关性.方法 收集284例脑梗死患者(脑梗死组)及335例同期健康体检者(对照组),采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测CYBA基因rs4673和rs3180279位点的基因型.结果 rs4673位点的基因型及等位基因频率分布在脑梗死组和对照组中差异无统计学意义(P＞0.05).脑卒中组男性患者rs3180279位点GC、GG基因型的频率低于对照组,CC基因型的频率高于对照组(P=0.034).结论 CYBA基因的rs4673位点与中国北方汉族人群的急性动脉硬化性脑梗死无相关性,男性rs3180279位点GG+GC基因型的携带者较CC基因型携带者动脉硬化性脑梗死的发病率可能更低.
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Key words
ischemic stroke,CYBA gene,polymorphism,restriction fragment length polymorphism
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