IL-33和IL1 RL1基因单核苷酸多态性与特应性皮炎相关性研究

Yan YANG,Quan CHEN,Yumei LIU,Xin ZHOU,Xin TIAN,Aili GAO,Siying XIONG,Xiaoyin CHEN,LIWei,Huilan ZHU

China journal of Leprosy and Skin Diseases（2020）

Cited 0|Views35

No score

Abstract

目的:分析IL-33和IL1RL1基因单核苷酸多态性(SNPs)与特应性皮炎(AD)的相关性.方法:PCR-SSP方法检测89例AD患者和138名正常对照组受试者IL-33和IL1RL1编码基因的等位基因和基因型频率.结果:AD患者的IL-33 rs1800925 C等位基因的频率高于对照组,而T等位基因和rs764706552等位基因G低于对照组(均P<0.001).IL-33 rs1800925基因型CC和rs764706552基因型CG与AD显著正相关(均P<0.001).两组患者的IL1RL1基因的等位基因和基因型频率无明显差异(均P>0.05).结论:IL-33基因可能与AD的发病相关.

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined