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皮肤病中蛋白激酶D1研究进展

Jing GU,Baoguo LIU,Meng ZHOU,Haifang ZHANG

China journal of Leprosy and Skin Diseases（2017）

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Abstract
蛋白激酶D1是一种在体内多个重要器官广泛表达的钙离子/钙调蛋白依赖性的丝氨酸/苏氨酸蛋白激酶,参与多种重要的生理和病理活动,在许多肿瘤组织中表达异常.PKD1促进角质形成细胞增殖,抑制其分化,对表皮伤口愈合及肿瘤的形成具有促进作用,与UVB、ROS等影响皮肤疾病发生发展的重要因素之间都有密切联系.因此PKD1可能成为治疗某些皮肤病甚至皮肤肿瘤更有效的分子靶点.
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Key words
protein kinase D1,keratinocytes,dermatosis
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