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盐酸博宁霉素对人表皮角质形成细胞、宫颈鳞癌细胞和表皮癌细胞增殖的影响

李新宇,高纪伟,徐兰芳,郑家润,陈汝贤,许鸿章

CHINA JOURNAL OF LEPROSY AND SKIN DISEASES（2009）

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Abstract
目的:探讨盐酸博宁霉素对人角质形成细胞HaCaT、人宫颈上皮癌细胞HeLa及人表皮癌细胞A431增殖的影响.方法:采用MTT法检测盐酸博宁霉素处理后培养的HaCaT细胞、HeLa细胞和A431细胞的增殖率.结果:盐酸博宁霉素能剂量依赖性抑制HaCaT细胞和HeLa细胞的增殖,IC50值分别为11.57 μg/mL和16.47 μg/mL, 但对A431细胞增殖的抑制作用较弱.结论:盐酸博宁霉素的细胞毒性是抗尖锐湿疣药物的治疗学基础.
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