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川陈皮素对MC3T3-E1细胞成骨分化影响的实验研究

LI-Qiang,Ting-chao LAN,LU-Yun,CHEN-Jing

Chinese Journal of Geriatric Dentistry（2019）

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Abstract
目的:检测川陈皮素对MC3T3-E1细胞增殖及成骨分化的作用及机制.方法:采用CCK-8法、碱性磷酸酶(ALP)活性检测及实时定量PCR方法评价川陈皮素对MC3T3-E1细胞增殖、成骨分化及相关基因表达的影响.结果:川陈皮素能促进MC3T3-E1的细胞增殖,刺激细胞ALP活性升高,上调BMP-2、COL-I、OCN、Runx2的基因表达,BMP-2信号阻断剂(Noggin)能抑制成骨分化基因表达.结论:川陈皮素可促进MC3T3-E1成骨分化及成骨基因表达,BMP-2信号通路可能参与了该过程.
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