IL-lβ和TNF-α对人牙周膜细胞内LIF表达的影响
Journal of Clinical Stomatology(2014)
Abstract
目的:探讨白细胞介素-lβ(IL-lβ)和肿瘤坏死因子-α(TNF-α)对牙周膜细胞内白血病抑制因子(LIF)表达的影响。方法:体外分离培养鉴定人牙周韧带细胞(HPDLC),取第3代细胞用于实验,利用牙周改建中高表达因子TNF-α和IL-1β刺激HPDLC后,实时定量反转录-聚合酶链反应检测LIF mRNA的表达。结果:IL-1β在浓度为0.1 ng/mL和5 ng/mL时,均显著促进LIF的分泌(P <0.01)。TNF-α在浓度为10 ng/mL时,明显促进LIF的分泌(P <0.05)。结论:牙周改建中高表达细胞因子IL-1β和TNF-α可促进牙周膜细胞中LIF的表达。
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Key words
interleukin-1β,tumor necrosis factor-α,leukemia inhibitory factor,human periodontal ligament cells
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