pEGFP-NeuroD重组质粒的构建及其在肝癌细胞中的表达
MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY（2009）
Abstract
神经分化因子1(NeuroD-1)又名B细胞E盒转录激活因子2(Beta-2),属于B类碱性螺旋-环-螺旋(bHLH)转录因子家族.NeuroD-1蛋白与广泛存在的A类bHLH蛋白E47形成异二聚体,激活胰岛素基因的转录,对胰腺β细胞的发育及生理功能有重要作用,被认为是治疗糖尿病的候选基因之一.
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