甲磺酸阿帕替尼联合TACE治疗中晚期肝癌的效果及对患者血清VEGF和MMP-9的影响
Chinese Journal of Interventional Radiology(Electronic Edition)(2019)
Abstract
目的:评价甲磺酸阿帕替尼联合经皮肝动脉化疗栓塞术(TACE)治疗中晚期肝癌的疗效及对血清血管内皮生长因子(VEGF)和基质金属蛋白酶(MMP)-9的影响.方法:选取2015年6月-12月瑞安市人民医院收治的中晚期肝细胞肝癌(HCC)患者46例,随机分为观察组、对照组,各23例,对照组仅采用TACE治疗,观察组在对照组的基础上给予甲磺酸阿帕替尼治疗,比较两组间的疗效、不良反应、血清VEGF及MMP-9水平.结果:观察组的疾病控制率明显高于对照组(56.52%vs.26.08%,P<0.05);观察组的半年生存率和1年生存率分别为52.17%和34.78%,对照组为34.78%和21.74%,差异均无统计学意义(P>0.05),但观察组的总生存率高于对照组,差异有统计学意义(34.78%vs.8.69%,P<0.05).观察组的不良反应发生率为56.5%,与对照组的65.2%差异无统计学意义.治疗前,两组血清VEGF[(232.54±17.05)ng/ml vs.(233.05±15.23)ng/ml]和MMP-9[(1857.23±15.31)ng/ml vs.(1883.45±15.42)ng/ml]差异均无统计学意义(P>0.05);术后1个月,观察组VEGF低于对照组[(206.04±13.05)ng/ml vs.(225.36±11.42)ng/ml],MMP-9也低于对照组[(1604.56±15.25)ng/ml vs.(1835.21±13.58)ng/ml],差异均有统计学意义(P<0.01).结论:TACE联合甲磺酸阿帕替尼治疗中晚期HCC的疗效优于单纯TACE.
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