药物洗脱支架对比传统腔内介入术治疗下肢动脉硬化闭塞症的META分析
Journal of Military Surgeon in in Southwest China(2018)
Abstract
目的 采用Meta分析的方法评价药物洗脱支架(DES)置入术与传统腔内介入术如普通球囊血管成形术(CBA)或金属裸支架(BMS)置入术治疗下肢动脉硬化闭塞症(LEAOD)的有效性及安全性.方法 检索关于腔内介入手术治疗下肢慢性缺血的文献,筛选后,采用RevMan 5.3软件进行Meta分析.结果 2组患者的术后长期无事件生存率(EFSR) (OR =1.89,95% CI:1.33-2.68)和短期通畅率(OR=3.62,95% CI:2.29-5.72)、长期通畅率(OR=2.34,95% CI:1.19-4.60)、保肢率(OR =2.41,95% CI:1.07-5.42)以及临床改善率(OR =2.17,95% CI:1.44-3.27)比较差异均有统计学意义,DES组较高;长期靶病变血管血运重建率(TLRR)(OR =0.41,95% CI:0.23-0.71)、短期TLRR(OR =0.35,95% CI:0.28-0.63)差异均有统计学意义,DSE组较低.但是2组患者死亡率(OR=0.77,95% CI:0.56-1.05,P=0.1)差异无统计学意义.结论 与传统腔内介入手术治疗LEAOD相比,DES置入术疗效显著,但安全性无明显差异.
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