HLA-DQA1基因多态性与川南地区汉族儿童支气管哮喘的相关性研究
Journal of Military Surgeon in in Southwest China(2015)
Abstract
目的:探讨人类白细胞抗原HLA-DQA1基因多态性与川南地区汉族儿童支气管哮喘的关联性,寻找与哮喘发作有关的易感基因和(或)抑制基因,为进一步研究哮喘发病机制、预防哮喘发作及寻找基因水平上治疗哮喘的方法提供相应的理论依据。方法采用聚合酶链反应-序列特异性引物(PCR-SSP)方法测定哮喘组(45例)、对照组(60例)HLA-DQAl等位基因,计算两组中各等位基因的基因频率并进行比较。结果(1)哮喘组HLA-DQA1*0301基因频率(20.00%)明显高于对照组(8.33%),P<0.05,有统计学意义,OR为3.333(95%置信区间为1.35~8.229)。(2)哮喘组HLA-DQA1*0104,基因频率(27.77%)明显低于对照组(38.33%),P<0.05,差异有统计学意义,OR为0.380(95%置信区间为0.164~0.880)。结论(1)HLA-DQA1*0301基因可能为儿童支气管哮喘的易感基因;(2)HLA-DQA1*0104基因可能为儿童哮喘的免疫抑制基因。
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Key words
bronchial asthma,HLA-DQA1 gene,susceptibility gene
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