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Ku70对同源重组修复蛋白Rad51的调节作用

杜利清,刘强,王彦,徐畅,曹嘉,付岳,陈凤华,樊飞跃

International Journal of Radiation Medicine and Nuclear Medicine（2013）

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Abstract
目的 研究非同源末端连接(NHEJ)蛋白Ku70对同源重组(HR)修复蛋白Rad51的调节作用,初步探讨HR与NHEJ间协同作用的机制.方法 采用Western blot法观察特异性增高和降低Ku70蛋白水平后Rad51蛋白表达水平的变化情况.结果 靶向Ku70基因小干扰RNA(siRNA)单纯转染组Rad51蛋白的表达水平较空白对照组明显下降；Ku70高表达载体PGCsi3.0-hKu70转染肿瘤细胞后,随着Ku70表达水平的升高,Rad51水平也随之升高.结论 Ku70可能对Rad51有正调控作用,NHEJ可能通过Ku70对Rad51的调节来实现其与HR的协同作用.
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Key words
DNA repair,Rad51 recombinase,RNA,small interfering,Ku70
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