仙灵骨葆胶囊治疗绝经后骨质疏松的疗效及其机制研究

The Chinese Journal of Clinical Pharmacology(2015)

Cited 4|Views12
No score
Abstract
目的:探讨仙灵骨葆胶囊治疗绝经后骨质疏松症( PMOP)的临床疗效及其对血清护骨素/细胞核因子κB受体活化因子配体( RANKL)的影响。方法患者随机分为2组,对照组口服元素钙600 mg? d-1和维生素D 0.25μg? d-1,在对照组基础上,试验组加用仙灵骨葆胶囊(1.5 g bid,口服)。疗程均为6个月。观察2组的临床疗效,测定骨密度,检测血清护骨素、RANKL水平。结果试验组,临床总有效率(93.30%)明显优于对照组(70.00%, P<0.05)。试验组,骨密度的提高(0.97±0.10,0.79±0.10)明显优于对照组(0.77±0.10,0.62±0.10)( P<0.05)。试验组,血清护骨素水平明显高于对照组(142.24±6.54 vs 119.18±5.71),而 RANKL 水平明显低于对照组(6.62±1.04 vs 8.46±1.63,P<0.05)。结论仙灵骨葆胶囊治疗PMOP具有良好的临床疗效,其作用机制可能与上调血清护骨素的表达、下调RANKL的表达有关。
More
Translated text
Key words
Xianlinggubao capsule,postmenopausal osteoporosis,osteoprotegerin,receptor activator of nuclear factor-κB ligand
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined