HPLC法测定知非沙班中R异构体
Drugs & Clinic(2014)
Abstract
目的:建立HPLC法测定知非沙班中R异构体的方法。方法采用HPLC法,以多糖衍生物共价键合手性柱Chirlpak?IA(250 mm×4.6 mm,5μm)作为固定相;以甲醇-乙腈-二乙胺(90∶10∶0.1)作为流动相;检测波长:235 nm;柱温:35℃;体积流量为0.85 mL/min;进样体积:20μL。结果知非沙班R异构体在0.0075~1.0000μg/mL与峰面积线性关系良好(r=0.9995),平均回收率为99.32%,RSD值为2.90%(n=12)。结论本法操作简便快速,结果准确可靠,可用于知非沙班中R异构体的控制。
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Key words
zifaxaban,R isomers,HPLC
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