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基于UPLC/Q-TOF-MS/MS对雷公藤次碱在小鼠体内代谢的分析

Xuan SHI,Yong YANG,Xiao-mei ZHANG,Xu-ming LIANG,Ji-chun RAN,Da-jian YANG,Yan-lei GUO

Chinese Journal of Hospital Pharmacy（2015）

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Abstract
目的:研究雷公藤次碱在小鼠体内的生物转化规律.方法:以昆明山海棠根皮提取物中雷公藤次碱为研究对象,借助UPLC/Q-TOF-MS/MS高分辨质谱系统,基于多重质量亏损技术,结合MetabolitePilot代谢物分析鉴定软件,系统分析雷公藤次碱在小鼠体内的代谢产物.结果:雷公藤次碱在小鼠体内经一系列生物转化后,生成包括氧化、N-乙酰化、脱C2H2O基团等在内的多种代谢产物.结论:本方法能鉴定雷公藤次碱在小鼠体内的生物转化规律,为中药昆明山海棠的临床使用提供重要参考.
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Key words
wilforine,metabolism,UPLC/Q-TOF-MS/MS,multiple mass defect filter
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