螺旋藻多糖对免疫低下小鼠的免疫调节作用
Chinese Journal of Hospital Pharmacy（2014）
Abstract
目的:观察螺旋藻多糖对环磷酰胺所致免疫低下小鼠免疫调节作用.方法:腹腔注射环磷酰胺制备免疫功能低下模型.用流式细胞术检测各组小鼠脾和胸腺细胞周期变化;运用比色法检测各组小鼠巨噬细胞吞噬功能及分泌IL-1功能;采用Greiss法检测各组小鼠巨噬细胞分泌NO功能.结果:螺旋藻多糖能增加免疫低下小鼠脾和胸腺S期和G2/M期的细胞;显著提高免疫低下小鼠巨噬细胞的免疫功能和分泌IL-1和NO的功能.结论:螺旋藻多糖能提高环磷酰胺所致免疫低下小鼠的免疫功能.
MoreKey words
polysacchrides Spirulina platensis,cyclophosphamide,immunoregulation,interleukin-1,nitric oxide
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