HPLC法测定盐酸丁卡因滴眼液中羟苯乙酯的含量
Northwest Pharmaceutical Journal(2015)
Abstract
目的:采用高效液相色谱法测定盐酸丁卡因滴眼液中抑菌剂羟苯乙酯的含量。方法色谱柱为 Agilent HC‐C18色谱柱(250 mm ×4.6 mm ,5μm);流动相为0.005 mol?L -1醋酸胺溶液(每1000 mL含三乙胺10 mL ;冰醋酸调pH5.0)‐乙腈(55∶45);检测波长为256 nm ;流速1.0 mL?min-1。结果羟苯乙酯质量浓度在14.31~143.12μg?mL -1范围内,与其峰面积呈良好的线性关系( r=1),平均回收率为99.0%(RSD=1.36%)。结论该方法专属性强、测定结果准确、精密度高、线性好,适用于检测盐酸丁卡因滴眼液中羟苯乙酯的含量。
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Key words
Tetracaine Hydrochloride Eye Drops,HPLC,ethylparaben,quantitative analysis
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