低分子右旋糖酐与呋塞米联用致不良反应1例
Chinese Journal of Drug Application and Monitoring(2014)
Abstract
1例41岁女性患者因肾病综合征给予低分子右旋糖酐注射液250 mL+呋塞米注射液40 mg,qd,ivgtt。输注至8 min时患者突然出现恶心、呕吐,伴腹痛、全身大汗、精神萎靡,测BP 95/70 mm Hg,HR 90~95次·min-1,立即停止输液。给予异丙嗪注射液(12.5 mg,im)、地塞米松注射液(5 mg,iv)以及奥美拉唑注射液(60 mg,iv),20 min后测BP 120/80 mm Hg,患者继而出现寒战,T 39.5℃,给予物理降温,肌注柴胡注射液4 mL。患者仍述腹痛,尤以下腹部明显,给予导尿,1 h后腹痛缓解,恶心、呕吐消失,3h后体温下降,患者病情逐渐平稳。
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Key words
Low molecular dextran,Furosemide,Adverse drug reaction,Gastrointestinal reaction,Arrhythmia
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