CYP2C9和CYP2C19基因多态性对药物代谢的影响及个体化用药研究进展
Chinese Journal of Drug Application and Monitoring(2014)
Abstract
CYP2C9、CYP2C19酶是细胞色素P450系统中重要的药物代谢酶,共同参与许多重要药物的体内代谢。CYP2C9、CYP2C19基因具有高度多态性,在基因编码区和非编码区存在许多碱基突变,这种突变会影响酶的活性,导致酶底物药物清除率改变,从而导致药品不良反应的发生。本文对CYP2C9、CYP2C19基因突变的发生频率及对药物代谢的影响做详细阐述。
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Key words
CYP2C9,CYP2C19,Genetic polymorphism
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