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氟西汀对卒中后抑郁大鼠行为学及海马神经元凋亡的影响

Libo ZHAO,Lu XU,Keke CHE,Bin QIN

Chinese Journal of Modern Applied Pharmacy（2014）

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Abstract
目的 探讨以氟西汀为代表的SSRIs对卒中后抑郁(post-stroke depression,PSD)大鼠行为学和神经元凋亡的影响.方法 用大脑中动脉线栓法(MCAO)建立大鼠局灶性脑缺血模型,再结合慢性不可预见的温和性应激(chronic unpredictable mild stress,CUMS)和孤养法建立PSD模型,加以10 mg·kg-1氟西汀干预.比较各组大鼠体质量与糖水消耗量;旷野实验测定直立活动和水平活动得分;流式细胞仪分析神经元细胞的凋亡率.结果 应激14d后,与PSD组大鼠比较,氟西汀干预组大鼠体质量和糖水消耗比例低(P＜0.05或P＜0.01),水平和垂直试验得分下降(P＜0.01),海马神经元凋亡率较高(P＜0.01).结论 氟西汀对PSD有一定的治疗作用.
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Key words
post-stroke depression,fluoxertin,apoptosis of hippocampal neurons
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