稀释剂对HPMC骨架片释药的影响
THE CHINESE JOURNAL OF MODERN APPLIED PHARMACY（2003）
Abstract
目的探讨稀释剂对难溶性药物的HPMC骨架片释药的影响.方法以甲氧苄胺嘧啶、卡马西平、磺胺甲口恶唑和茶碱四种难溶型性药物为模型药物,测定三种相同剂量的稀释剂(糊精、乳糖和磷酸氢钙)时药物的释放度.结果甲氧苄胺嘧啶、卡马西平、磺胺甲口恶唑的释药速率为糊精＞乳糖＞磷酸氢钙;而茶碱的释药速率为糊精≈乳糖＞磷酸氢钙.结论稀释剂对难溶性药物HPMC骨架片释药的影响同药物HPMC骨架片的释药机制有关.
MoreAI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined