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糖尿病性肌少症发病机制和治疗靶点的研究进展

Fan DING,Wenxiong LI,Jiali ZHANG,Yan ZHANG

Chinese Journal of Clinical Pharmacology and Therapeutics（2019）

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Abstract
糖尿病是一种以高血糖为特征的代谢性疾病,肌少症是其常见的慢性并发症之一.糖尿病性肌少症可能与泛素-蛋白酶体系统、胰岛素抵抗、氧化应激、线粒体损伤、胰岛素信号通路、晚期糖基化终末产物有关.本文根据国内外文献,对糖尿病性肌少症的发病机制和治疗靶点进行综述.
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Key words
diabetic sarcopenia,pathology mechanism
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