熊脱氧胆酸在慢性肝病中应用及机制的再认识
Chinese Journal of Clinical Pharmacology and Therapeutics（2017）
Abstract
熊脱氧胆酸(ursodeoxycholic acid,UDCA)具有“保肝作用”,广泛应用于治疗各种慢性肝病,包括原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)、原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)、囊性纤维化(cystic fibrosis,CF)等,缺乏阳性药物对照,故对UDCA治疗慢性肝病的临床疗效机制尚不十分明确.近年来,由于UDCA不良事件报道日益增多,尤其在高剂量下,UDCA已表现出显著毒性.本文对UDCA在慢性肝病的临床应用及其机制进行探讨,为临床合理应用UDCA治疗肝病提供参考.
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Key words
ursodeoxycholic acid,liver disease,cholagogue,toxicity
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