芦丁自微乳的体外释放行为研究

Huiru Zhao, Beibei Li,Hui Jing,Yang Yang,Xiaojing Xu,Junchang Bian

China Pharmacist（2019）

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Abstract

目的:考察芦丁自微乳的体外释放行为.方法:采用HPLC测定芦丁的含量,分别以pH 1.2盐酸、pH 6.863磷酸缓冲液和蒸馏水为释放介质,绘制芦丁自微乳的释药曲线并进行模型拟合;应用相似因子评价芦丁自微乳和原料药体外释放行为.结果:芦丁自微乳在3种不同介质中的释放行为均可用Hixson-Crowell立方根方程拟合,芦丁原料药和自微乳的体外释放特征有差异.结论:自微乳改善了芦丁的体外释放行为,能显著加快其溶出.

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