单凝聚法制备姜黄素微囊的工艺研究
China Pharmacist（2019）
Abstract
目的:优化姜黄素微囊的制备工艺.方法:采用单凝聚法制备姜黄素微囊,以包封率、载药量和产率为指标,采用正交试验对明胶浓度、芯壁比、成囊温度、搅拌速度等因素进行考察,并对其形态与粒径进行表征.结果:单凝聚法制备姜黄素微囊的最优处方为:明胶浓度5％,芯壁比1∶2,成囊温度50℃,搅拌速度500 r·min-.制备的姜黄素微囊外观圆整,大小均匀且无粘连.结论:单凝聚法制备姜黄素微囊工艺简单,包封率高,载药量大.
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