30例利伐沙班致肝损伤文献分析
Chinese Journal of New Drugs(2019)
Abstract
目的:分析利伐沙班致肝损伤的发生规律及特点,为安全用药提供参考.方法:检索中国学术期刊全文数据库、维普中文科技期刊数据库、万方数据库和PubMed数据库收载的利伐沙班上市后致肝损伤文献进行分析.结果:30例不良反应中,男性12例,女性18例,年龄60岁及以上患者22例(73.3%).22例在用药5周内发生肝损伤.30例患者中,肝细胞型肝损伤13例.临床表现主要为黄疸、恶心及疲劳不适等.结论:老年人可能更易发生肝损伤,应加强利伐沙班致肝损伤监测,以便及时发现和处理肝损伤.
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