治疗婴幼儿血管瘤的盐酸普萘洛尔乳膏处方及制备工艺研究
Pharmaceutical Care and Research（2018）
Abstract
目的:研究盐酸普萘洛尔乳膏处方及其制备工艺,用于治疗婴幼儿表面血管瘤.方法:采用正交试验优化盐酸普萘洛尔乳膏处方及制备工艺.优化处方组成,包括油相、水相、乳化剂比例.优化工艺包括乳化温度、乳化速度.结果:经过正交试验优化后,所制样品均匀、细腻,色泽光亮,涂展性和稳定性好.盐酸普萘洛尔含量为标示量的99.88% ~102.89%.结论:盐酸普萘洛尔乳膏处方合理,制备工艺可行,含量稳定.
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Key words
propranolol hydrochloride cream,formulation,preparation technology,orthogonal experiment
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