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[18F]F-DOPA合成方法的研究进展

Weihua CHENG,Feihu GUO,Xuesong DENG,Xiangyu QIN,Hongqiang FAN,Ji HU

Journal of China Pharmaceutical University（2019）

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Abstract
6-[18F]氟-3,4-二羟基-L-苯丙氨酸([18F]F-DOPA)作为帕金森病的诊断试剂已应用30多年.目前应用的亲电合成方法存在着放化产率(RCY)低、比活度(SA)低等缺点,而近年来亲核取代合成[18F]F-DOPA的方法以无载体的[18F]F-作为亲核进攻试剂,可以克服以上缺点.本文综述了近年来报道的[18 F]F-DOPA亲核取代合成的新方法.
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f-dopa
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