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当归芍药散对β-淀粉样蛋白致PC12细胞损伤的保护作用

Zhi-hong LIN,Yong-qing YAN,Dan-Ni ZHU,Bo-yang YU,Qiu-Juan WANG

JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY（2005）

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Abstract
目的:观察当归芍药散(Danggui Shaoyao San,DSS)对β淀粉样蛋白(A325-35)诱导的PC12细胞损伤的保护作用.方法:制备含DSS脑脊液(CSF-DSS)与含DSS人工脑脊液(ACSF-DSS),应用Aβ25-35诱导PC12细胞损伤,MTT法测定细胞活力和比色法测定细胞内过氧化氢酶(CAT)活性.结果:10 μmol/L Aβ25-35可显著降低PC12细胞活力及CAT活性;5 mg/L ACSF-DSS和0.93 g/kg-0.5%、1.86 g/kg-11.0%CSF-DSS均可显著提高细胞活力与CAT活性.结论:DSS可能通过提高CAT活性而对Aβ25-35诱导的PC12细胞损伤起到保护作用.
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