正交试验优选消肿止痛膜气雾剂的工艺配方研究
Journal of North Pharmacy(2015)
Abstract
目的::优选消肿止痛膜气雾剂工艺配方。方法:以壳聚糖盐酸盐、聚乙烯吡咯烷酮PVPK30、HPMC、消肿止痛药方乙醇提取液的水平用量为考察因素,以成膜性能、成膜时间及喷射效果为指标,采用L9(34)正交试验优选消肿止痛膜气雾剂工艺配方。结果:消肿止痛膜气雾剂的最佳工艺配方为壳聚糖盐酸盐含量3%,HPMC含量0.3%,PVPK30含量3%和药方乙醇提取液30%。结论:该工艺配方合理、可行,适用于消肿止痛膜气雾剂的制备。
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Key words
Swell-relieving and pain-killing aerosol,Technical formulation,Orthogonal test
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