羟苯磺酸钙胶囊致中毒性表皮坏死松解症2例

Adverse Drug Reactions Journal（2018）

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Abstract

2例女性患者(例1,63岁;例2,51岁)因高血压病和慢性肾功能不全服用羟苯磺酸钙胶囊0.5 g,3次/d.例1于服药第15天左上肢出现红色皮疹伴高热,例2于服药第20天躯干和双大腿部出现红色皮疹,伴咳嗽和高热;分别于出疹后1 d(例1)和3 d(例2)发展至全身皮疹;分别于出疹后3 d(例1)和9 d(例2)出现口腔、双眼、外阴黏膜处破溃.诊断:羟苯磺酸钙胶囊致中毒性表皮坏死松解症.停用羟苯磺酸钙胶囊,给予糖皮质激素、人免疫球蛋白、补钾、补钙等治疗.分别在治疗13 d(例1)和18 d(例2)黏膜糜烂处愈合或好转,16 d(例1)和25 d(例2)后皮疹消退.

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Key words

Calcium dobesilate,Epidermal necrolysis,toxic

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