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注射用白眉蛇毒血凝酶致低纤维蛋白原血症2例

wf(2016)

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Abstract
2例患者(例1女,78岁;例2男,39岁)分别因左下腹包块出血和外伤致休克而静脉滴注注射用白眉蛇毒血凝酶(4 KU/ d),分别于用药8和4 d 后出现纤维蛋白原水平降低(例1,1.49 g/ L降至0.71 g/ L;例2,2.01 g/ L 降至0.52 g/ L),伴明显活动性出血。考虑低纤维蛋白原血症为注射用白眉蛇毒血凝酶所致。均停药并输注血浆冷沉淀,治疗5 d 后,例1纤维蛋白原升至2.01 g/ L,腹部超声结果提示左下腹未见活动性出血;例2纤维蛋白原升至3.44 g/ L,胸腔引流管液体为淡红色。
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Key words
Afibrinogenemia,Hemocoagulase for injection
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