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右美托咪定预处理对CLP大鼠急性肾损伤的保护作用

Shan CHEN,Wei-fang WU,Yi-long WU, Lian-ping CHEN,Shi-qi CHEN,Jie LIN, Qing-qing ZHAO, Jia-lin HUANG,Zhi-feng CHEN, Zheng-rong XU, Fei-hong LIANG, Xin-yue YAN, Hui-yun DENG,Ya-li HUANG

Strait Pharmaceutical Journal（2019）

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Abstract
目的 观察右美托咪定预处理对盲肠结扎穿孔(CLP)脓毒症模型大鼠急性肾损伤的影响及TLR4表达变化.方法 24只大鼠随机分为三组,假手术(SHAM)组,模型(CLP)组和右美托咪定(DEX)组,每组8只,各组在造模前30min分别腹腔注射等剂量生理盐水或右美托咪定100μg·kg-,随后行CLP造模并观察24h,酶联免疫吸附法测定血清TNF-α和IL-6,HE染色观察肾组织病理结构变化,荧光定量PCR测定肾组织TLR4 mRNA表达.结果 与 CLP组比较,DEX组血清TNF-α和IL-6含量明显减少(P＜0.01),肾组织的损伤情况明显减轻,TLR4 mRNA表达亦显著减少(P＜0.01).结论 右美托咪定预处理能减轻脓毒症引起的肾组织炎症反应,具有一定保护作用.
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