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丹皮酚自微乳处方设计研究

Quyn-hvan LUU,Lin ZHANG,Gui-hong YU,feng-zhi ZHAO,Xin-hong SHI

Strait Pharmaceutical Journal（2017）

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Abstract
目的 研究丹皮酚自微乳的处方设计.方法 采用测定溶解度,绘制伪三元相图和星点设计法筛选及优化处方.结果 以油酸乙酯(EO)为油相、聚氧乙烯辛基苯基醚(OP-10)为乳化剂、二乙二醇单乙基醚(HP)为助乳化剂,比例为24.47％∶50.35％∶25.18％时能形成稳定的丹皮酚自微乳.结论 丹皮酚自微乳处方设计方法简单,结果可靠,性质稳定.
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