格列吡嗪控释片在人体内的药动学
CHINESE JOURNAL OF CLINICAL PHARMACY(2005)
Abstract
目的建立人血浆中格列吡嗪(Gli)浓度测定的HPLC法,观察Gli控释片在人体内的药动学特征.方法20名受试者单剂量口服Gli控释片10 mg后,在规定时间取血,采用HPLC法测定血药浓度.用统计矩法计算药动学参数,AUC用梯形法计算,tmax和cmax为实测值.结果单剂量口服Gli控释片后的药动学参数为:AUCo→48(4371.3±1 474.5)μg·h·L-1,AUC0→∞(4 952.2±2 110.5)μg·h·L-1,tmax(6.74±2.77)h,cmax(200.1±54.20)μg·L-1,MRT(16.67±1.73)h.结论Gli控释片达到缓释24h的效果.
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