醋酸地塞米松脂质体滴眼液的制备
Central South Pharmacy（2017）
Abstract
目的 制备醋酸地塞米松脂质体滴眼液,考察包封率及粒径的影响因素并进行质量评价.方法 以葡聚糖凝胶分离脂质体和游离醋酸地塞米松;采用紫外分光光度法测定醋酸地塞米松脂质体滴眼液的包封率.考察制备工艺和处方因素对醋酸地塞米松脂质体滴眼液的包封率及粒径的影响.评价醋酸地塞米松脂质体滴眼液的质量.与醋酸地塞米松滴眼液相比,考察醋酸地塞米松脂质体滴眼液的眼部滞留时间.结果 通过优化制备工艺和处方,醋酸地塞米松脂质体滴眼液的包封率达88.70％,粒径为133.8nm,醋酸地塞米松脂质体滴眼液的眼部滞留时间是普通滴眼液的4倍.结论 制备的醋酸地塞米松脂质体滴眼液包封率较高,粒径小,显著延长了药物的滞留时间,方法可行.
MoreKey words
dexamethasone acetate,ophthalmic liposomal solution,entrapment efficiency,size
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