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蕲蛇抗栓酶注射液稳定性的研究

Lv Weifeng,Wang Yue,Liu Yun,Le Suqing,Gao Xiang-dong

PHARMACEUTICAL BIOTECHNOLOGY（2004）

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Abstract
为获取对蕲蛇抗栓酶(acutobin)注射液的酶活有保护作用且使制剂稳定的保护剂配方,本实验设计了7个单方及四组正交实验共16个保护剂处方,以加入保护剂的蕲蛇抗栓酶为样品,未加保护剂的为空白对照,在37℃温度加速实验下,间隔一定时间观测蕲蛇抗栓酶制剂的酶活及澄明度的变化.结果,单方氨基酸和小肽类的加入使酶活力保存率提高,而多元醇类的加入使澄明度得到改善;复方保护剂的加入对蕲蛇抗栓酶的保护作用不明显.
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Key words
acutobin,stabilization
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