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Liguzinediol的合成

Ying ZHOU,Wei LI,Lei CHEN, Shiwei CHEN,Tianlin WANG

Chinese Journal of Pharmaceuticals（2014）

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Abstract
Liguzinediol（1）,化学名为2,5-二羟甲基-3,6-二甲基吡嗪,对正常以及急、慢性心力衰竭模型大鼠心脏具有较强的正性肌力作用,且无心律失常等不良反应[1-4]。1可通过作用于心肌细胞内的SERCA2a靶点发挥正性肌力作用[5]。研究表明[6-8],
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Key words
liguzinediol,radical reaction,hydroxymethylation,synthesis
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